Caging and COM-Bating Antibiotic Resistance

Antibiotics and Antibiotic Resistance

A AAC(60)-Ib-cr, 185 ACHN-975 clinical studies, 163–164 medicinal chemistry, 166 structure, 162 AcrAB-TolC, 180 AcrD, 236 AdeRS, 257 AFN-1252 mechanism of action, 148, 153 resistance, 153 structure, 149 AIM-1, 74 Amicoumacin A, 222 Amikacin indications, 240 structure, 230 synthesis, 4 Aminoglycosides. See also specific drugs historical perspective, 229–230 indications, 239–241 mechanism of acti...

Antibiotic resistance and pyelonephritis.

Increasing antibiotic resistance threatens our ability to effectively treat bacterial infections. Antibiotic therapy enhances the growth of existing drug-resistant bacteria and the exchange of resistance mechanisms between bacteria (and even between species) and selects for resistance mutations. The effect on levels of drug-resistant infection in the population of treating 1000 people with anti...

Caging and Uncaging Genetics

It is important for biology to understand if observations made in highly reductionist laboratory settings generalise to harsh and noisy natural environments in which genetic variation is sorted to produce adaptation. But what do we learn by studying, in the laboratory, a genetically diverse population that mirrors the wild? What is the best design for studying genetic variation? When should we ...

Antibiotic Resistance

Antibiotic resistance is an ongoing evolutionary process that has been the concern of infectious disease specialists since antibiotic use gained popularity. Antibiotic resistance is not a concern of the public as reflected by their desire for antibiotics whenever illness occurs. Patients can and do pressure their physicians for antibiotics ; 12 million antibiotic prescriptions were filled for u...

antibiotic prescription and bacterial resistance